Karyopharm Therapeutics Inc. (KPTI) is a publicly traded company in the Unknown sector. Across all available filings, 30 corporate insiders have executed 738 transactions totaling $180.3M, demonstrating a bearish sentiment with -$159.7M in net insider flow. The most recent transaction on Jan 21, 2026 involved a sale of 265 shares valued at $1.6K.
No significant insider buying has been recorded for KPTI in the recent period.
No significant insider selling has been recorded for KPTI in the recent period.
Based on recent SEC filings, insider sentiment for KPTI is bearish with an Insider Alignment Score of 6/100 and a net flow of -$159.7M. Insiders are reducing their positions, though this can be driven by factors unrelated to company outlook.
Insider trading at Karyopharm Therapeutics Inc. (KPTI) refers to stock transactions made by corporate insiders—executives, directors, and beneficial owners holding more than 10% of the company's shares. These individuals have access to material non-public information and are required by law to report their trades to the SEC within two business days. Currently, 30 insiders are actively trading KPTI stock, having executed 738 transactions in the past 90 days. The most active insider is Marcin Czernik (Executive), who has made 35 transactions totaling $30.6M.
Get notified when executives and directors at KPTI file new Form 4 transactions
Date | Insider | Title | Type | Shares | Price | Value | Flags |
|---|---|---|---|---|---|---|---|
| Jan 21, 2026 | Abate Kristin | Chief Accounting Officer | Sale | 265 | $5.96 | $1.6K | |
| Oct 15, 2025 | Macomber Lori | Executive | Award | 43,650 | $N/A | $0 | |
| Oct 15, 2025 | Roshan Cheng Sohanya | Executive | Award | 43,650 | $N/A | $0 | |
| Oct 15, 2025 | A. Paulson Richard | Executive | Award | 114,285 | $N/A | $0 | |
| Oct 15, 2025 | Mano Michael | Executive | Award | 43,650 | $N/A | $0 | |
| Oct 15, 2025 | Poulton Stuart | Executive | Award | 39,682 | $N/A | $0 | |
| Oct 15, 2025 | Abate Kristin | Executive | Award | 12,799 | $N/A | $0 | |
| Oct 1, 2025 | Abate Kristin | Executive | Sale | 362 | $6.30 | $2.3K | |
| Sep 15, 2025 | Abate Kristin | Executive | Sale | 23 | $6.43 | $148 | |
| Sep 15, 2025 | Roshan Cheng Sohanya | Executive | Sale | 325 | $6.43 | $2.1K | |
| Sep 15, 2025 | Rangwala Reshma | Executive | Sale | 408 | $6.43 | $2.6K | |
| Sep 15, 2025 | Poulton Stuart | Executive | Sale | 401 | $6.43 | $2.6K | |
| Sep 15, 2025 | Mano Michael | Executive | Sale | 234 | $6.43 | $1.5K | |
| Sep 15, 2025 | A. Paulson Richard | Executive | Sale | 1,257 | $6.43 | $8.1K | |
| Sep 12, 2025 | Abate Kristin | Executive | Award | 46 | $N/A | $0 |
| TYPE | COUNT | VALUE | % |
|---|---|---|---|
Sale(S) | 442 | $170.0M | 91.5% |
Purchase(P) | 22 | $10.3M | 5.6% |
Exercise(M) | 193 | $5.3M | 2.8% |
Award(A) | 58 | $147.8K | 0.1% |
Payment(F) | 1 | $6.5K | 0.0% |
Gift(G) | 14 | $0 | 0.0% |
Conversion(C) | 8 | $0 | 0.0% |
Insider selling pressure at Karyopharm Therapeutics Inc. has increased, with 30 insiders executing 738 transactions across all time. Total sales of $170.0M significantly outpace purchases of $10.3M, resulting in a net outflow of $159.7M. This selling activity appears largely discretionary, which may warrant closer attention from investors.