Protagonist Therapeutics, Inc

Protagonist Therapeutics, Inc insiders are currently net buyers of PTGX stock, showing neutral sentiment over the past 90 days. Executives have purchased $35.5M while selling $32.1M, resulting in a positive net flow of $3.4M. This buying activity represents 53% of total transaction volume.

Protagonist Therapeutics, Inc has 22 active insiders who have filed SEC Form 4 transactions in the past 90 days. Dinesh V. Ph D. Patel (Executive) leads with 69 transactions totaling $17.1M. Partners X. Llc Canaan (Executive) follows with 12 transactions worth $10.2M. Open-market purchases require insiders to invest their own capital, demonstrating genuine conviction.

The Insider Alignment Score measures the ratio of buying to selling activity on a 0-100 scale. Protagonist Therapeutics, Inc's current score of 53/100 indicates neutral insider sentiment. Scores between 40-60 represent neutral or mixed activity. With $35.5M in purchases and $32.1M in sales, no strong directional conviction is evident.

The most recent insider transaction occurred on Mar 26, 2026, when E. Selick Harold (Executive) disposed of 24,000 shares at $0.00 per share for $0. This appears to be a discretionary trade.

Based on SEC Form 4 filings from the past 90 days, PTGX insider trading sentiment is currently neutral with an Alignment Score of 53/100. The balanced activity—$35.5M bought vs $32.1M sold—suggests no strong consensus among insiders.

SEC Form 4 is the primary disclosure mechanism for insider trading at publicly traded companies like Protagonist Therapeutics, Inc. Corporate insiders must file within two business days of any transaction, making it one of the most timely sources of executive sentiment. At PTGX, we track all Form 4 filings—currently showing 274 transactions from 22 insiders over 90 days.

A 10b5-1 plan allows Protagonist Therapeutics, Inc executives to pre-schedule stock sales when they don't possess material non-public information. At PTGX, approximately 0% of recent transactions are 10b5-1 trades. Most trading activity at PTGX appears discretionary, making insider signals more meaningful.

You can monitor Protagonist Therapeutics, Inc (PTGX) insider trading activity on this page, which updates within hours of new SEC Form 4 filings. We track all 22 active insiders and provide real-time transaction feeds, the Alignment Score, 10b5-1 vs. discretionary breakdowns, and direct links to SEC EDGAR filings.

Our Alignment Score measures the ratio of insider buying to selling on a scale of 0-100. A score above 70 indicates strong bullish sentiment, while below 30 suggests bearish activity. Protagonist Therapeutics, Inc's current score of 53/100 indicates neutral sentiment with balanced buying and selling activity. This is calculated from $35.5M in purchases versus $32.1M in sales over 90 days, resulting in a net flow of $3.4M.

SEC Form 4 filings are mandatory reports that Protagonist Therapeutics, Inc insiders must submit within 2 business days. Each filing includes the insider's name, relationship, transaction type, shares, and price. Transaction codes: P (purchase), S (sale), A (award), M (option exercise), G (gift). At PTGX, the most common type is "S" with 16 occurrences. The most recent Form 4 was filed on Mar 26, 2026 by E. Selick Harold.

Rule 10b5-1 allows corporate insiders to establish pre-scheduled trading plans when they don't possess material non-public information. At Protagonist Therapeutics, Inc, approximately 0% of recent transactions are executed under 10b5-1 plans, while 100% appear to be discretionary trades. The low percentage means most insider activity at PTGX represents discretionary decisions with more informational value.