Septerna, Inc.

Septerna, Inc. insiders are currently net sellers of SEPN stock, showing bearish sentiment over the past 90 days. Total sales of $63.2K outpace purchases of $0, creating a net outflow of $63.2K.

Septerna, Inc. has 10 active insiders who have filed SEC Form 4 transactions in the past 90 days. Uwe Klein (SVP, Biological Sciences) leads with 4 transactions totaling $94.4K. Daniel D. Long (SVP, Drug Discovery) follows with 2 transactions worth $63.2K. Open-market purchases require insiders to invest their own capital, demonstrating genuine conviction.

The Insider Alignment Score measures the ratio of buying to selling activity on a 0-100 scale. Septerna, Inc.'s current score of 0/100 indicates bearish insider sentiment. Scores below 40 indicate selling pressure exceeds buying. Insider selling often reflects diversification needs, tax optimization, or estate planning.

The most recent insider transaction occurred on Feb 6, 2026, when Andrew Wilson Mark (Chief Legal Officer) acquired 165,000 shares at $0.00 per share for $0. This appears to be a discretionary trade.

Based on SEC Form 4 filings from the past 90 days, SEPN insider trading sentiment is currently bearish with an Alignment Score of 0/100. The negative net flow of $63.2K shows more selling than buying. However, 0% of recent transactions are 10b5-1 scheduled trades.

SEC Form 4 is the primary disclosure mechanism for insider trading at publicly traded companies like Septerna, Inc.. Corporate insiders must file within two business days of any transaction, making it one of the most timely sources of executive sentiment. At SEPN, we track all Form 4 filings—currently showing 16 transactions from 10 insiders over 90 days.

A 10b5-1 plan allows Septerna, Inc. executives to pre-schedule stock sales when they don't possess material non-public information. At SEPN, approximately 0% of recent transactions are 10b5-1 trades. Most trading activity at SEPN appears discretionary, making insider signals more meaningful.

You can monitor Septerna, Inc. (SEPN) insider trading activity on this page, which updates within hours of new SEC Form 4 filings. We track all 10 active insiders and provide real-time transaction feeds, the Alignment Score, 10b5-1 vs. discretionary breakdowns, and direct links to SEC EDGAR filings.

Our Alignment Score measures the ratio of insider buying to selling on a scale of 0-100. A score above 70 indicates strong bullish sentiment, while below 30 suggests bearish activity. Septerna, Inc.'s current score of 0/100 indicates bearish sentiment with significant insider selling pressure. This is calculated from $0 in purchases versus $63.2K in sales over 90 days, resulting in a net flow of -$63.2K.

SEC Form 4 filings are mandatory reports that Septerna, Inc. insiders must submit within 2 business days. Each filing includes the insider's name, relationship, transaction type, shares, and price. Transaction codes: P (purchase), S (sale), A (award), M (option exercise), G (gift). At SEPN, the most common type is "A" with 8 occurrences. The most recent Form 4 was filed on Feb 6, 2026 by Andrew Wilson Mark.

Rule 10b5-1 allows corporate insiders to establish pre-scheduled trading plans when they don't possess material non-public information. At Septerna, Inc., approximately 0% of recent transactions are executed under 10b5-1 plans, while 100% appear to be discretionary trades. The low percentage means most insider activity at SEPN represents discretionary decisions with more informational value.