Joseph Klein III serves as Executive at ISIS PHARMACEUTICALS INC, where they oversee executive responsibilities. Since joining the company, Joseph Klein III has executed 349 insider transactions totaling $16.4M, demonstrating a bearish approach to their equity position. Their most recent transaction on Nov 25, 2025 involved exercising options for 4,000 shares valued at $0.
Joseph Klein III currently holds 4,000 shares of ISIS PHARMACEUTICALS INC (ISIS), valued at approximately $0. This represents their equity stake as Executive.
Based on SEC Form 4 filings, Joseph Klein III has been a net seller of ISIS stock. They have purchased $936.4K and sold $15.4M worth of shares.
Joseph Klein III's most recent insider trade was on Nov 25, 2025, when they sold 4,000 shares at $0.00 per share.
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| $80.00 |
| Discretionary |
| Nov 25, 2025 | IONS | $0 | Option Exercise | 4,000 | $N/A | Discretionary |
| Nov 25, 2025 | IONS | $320.0K | Sale | 4,000 | $80.00 | Discretionary |
| Nov 25, 2025 | IONS | $0 | Option Exercise | 4,000 | $N/A | Discretionary |
| Nov 25, 2025 | IONS | $320.0K | Sale | 4,000 | $80.00 | Discretionary |
| Sep 3, 2025 | IONS | $1.7M | Sale | 28,000 | $60.00 | Discretionary |
| Sep 3, 2025 | IONS | $0 | Option Exercise | 16,000 | $N/A | Discretionary |
| Sep 3, 2025 | IONS | $0 | Option Exercise | 12,000 | $N/A | Discretionary |
| Sep 3, 2025 | IONS | $1.7M | Sale | 28,000 | $60.00 | Discretionary |
| Sep 3, 2025 | IONS | $0 | Option Exercise | 16,000 | $N/A | Discretionary |
| Sep 3, 2025 | IONS | $0 | Option Exercise | 12,000 | $N/A | Discretionary |
| Jul 16, 2024 | IONS | $293.0K | Option Exercise | 12,000 | $24.42 | Planned |
| Jul 16, 2024 | IONS | $600.0K | Sale | 12,000 | $50.00 | Planned |
| May 3, 2024 | IONS | $31.4K | Sale | 731 | $42.98 | Planned |
| May 3, 2024 | IONS | $54.0K | Sale | 1,269 | $42.59 | Planned |
| May 3, 2024 | IONS | $39.9K | Sale | 930 | $42.90 | Planned |
| May 3, 2024 | IONS | $56.1K | Sale | 1,318 | $42.57 | Planned |
| May 3, 2024 | IONS | $45.5K | Sale | 1,070 | $42.55 | Planned |
| May 3, 2024 | IONS | $29.3K | Sale | 682 | $42.94 | Planned |
| Nov 15, 2023 | IONS | $100.0K | Sale | 2,000 | $50.00 | Planned |
| Sep 26, 2023 | IONS | $90.3K | Sale | 2,000 | $45.13 | Planned |
| Jul 18, 2023 | IONS | $149.3K | Sale | 3,555 | $42.00 | Discretionary |
| Jul 17, 2023 | IONS | $0 | Option Exercise | 1,777 | $N/A | Discretionary |
| Jul 17, 2023 | IONS | $0 | Option Exercise | 5,333 | $N/A | Discretionary |
| Jan 17, 2023 | IONS | $80.0K | Sale | 2,000 | $40.00 | Discretionary |
| Jul 15, 2022 | IONS | $25.0K | Sale | 644 | $38.78 | Discretionary |
| Jul 15, 2022 | IONS | $26.0K | Sale | 689 | $37.74 | Discretionary |
| Jul 15, 2022 | IONS | $0 | Option Exercise | 2,665 | $N/A | Discretionary |
| Jul 15, 2022 | IONS | $0 | Option Exercise | 5,333 | $N/A | Discretionary |