Patrick R. O'neil serves as Executive at ISIS PHARMACEUTICALS INC, where they oversee executive responsibilities. Since joining the company, Patrick R. O'neil has executed 333 insider transactions totaling $34.0M, demonstrating a bearish approach to their equity position. Their most recent transaction on Jan 30, 2026 involved selling 6,179 shares valued at $516.2K.
Patrick R. O'neil currently holds 71,983 shares of ISIS PHARMACEUTICALS INC (ISIS), valued at approximately $0. This represents their equity stake as Executive.
Based on SEC Form 4 filings, Patrick R. O'neil has been a net seller of ISIS stock. They have purchased $0 and sold $34.0M worth of shares.
Patrick R. O'neil's most recent insider trade was on Jan 30, 2026, when they sold 6,179 shares at $83.53 per share.
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| $N/A |
| Discretionary |
| Jan 2, 2026 | IONS | $0 | Award | 19,350 | $N/A | Discretionary |
| Oct 6, 2025 | IONS | $224.5K | Sale | 3,241 | $69.27 | Discretionary |
| Oct 6, 2025 | IONS | $539.3K | Option Exercise | 10,200 | $52.87 | Discretionary |
| Oct 6, 2025 | IONS | $712.9K | Sale | 10,200 | $69.89 | Discretionary |
| Oct 2, 2025 | IONS | $2.1M | Option Exercise | 34,461 | $60.89 | Discretionary |
| Oct 2, 2025 | IONS | $2.0M | Sale | 30,203 | $67.69 | Discretionary |
| Oct 2, 2025 | IONS | $1.7M | Option Exercise | 30,203 | $56.78 | Discretionary |
| Oct 2, 2025 | IONS | $2.3M | Sale | 34,461 | $67.69 | Discretionary |
| Sep 30, 2025 | IONS | $841.9K | Option Exercise | 14,827 | $56.78 | Discretionary |
| Sep 30, 2025 | IONS | $959.0K | Sale | 14,827 | $64.68 | Discretionary |
| Sep 29, 2025 | IONS | $675.9K | Sale | 10,473 | $64.54 | Discretionary |
| Sep 29, 2025 | IONS | $594.7K | Option Exercise | 10,473 | $56.78 | Discretionary |
| Sep 12, 2025 | IONS | $96.5K | Option Exercise | 1,700 | $56.78 | Discretionary |
| Sep 12, 2025 | IONS | $109.8K | Sale | 1,700 | $64.58 | Discretionary |
| Sep 9, 2025 | IONS | $64.6K | Sale | 1,000 | $64.56 | Discretionary |
| Sep 9, 2025 | IONS | $56.8K | Option Exercise | 1,000 | $56.78 | Discretionary |
| Sep 9, 2025 | IONS | $1.3M | Sale | 20,000 | $64.56 | Discretionary |
| Sep 9, 2025 | IONS | $1.2M | Option Exercise | 20,000 | $60.89 | Discretionary |
| Sep 3, 2025 | IONS | $2.7M | Option Exercise | 49,800 | $53.77 | Discretionary |
| Sep 3, 2025 | IONS | $698.7K | Sale | 11,375 | $61.42 | Discretionary |
| Sep 3, 2025 | IONS | $425.4K | Option Exercise | 13,050 | $32.60 | Discretionary |
| Sep 3, 2025 | IONS | $4.0M | Sale | 65,475 | $60.89 | Discretionary |
| Sep 3, 2025 | IONS | $526.1K | Option Exercise | 14,000 | $37.58 | Discretionary |
| Sep 2, 2025 | IONS | $711.4K | Sale | 13,050 | $54.51 | Discretionary |
| Sep 2, 2025 | IONS | $425.4K | Option Exercise | 13,050 | $32.60 | Discretionary |
| Aug 29, 2025 | IONS | $9.2K | Other | 331 | $27.71 | Discretionary |
| Aug 30, 2024 | IONS | $9.5K | Other | 246 | $38.64 | Discretionary |
| Feb 2, 2024 | IONS | $99.1K | Sale | 1,995 | $49.67 | Discretionary |