Spencer R. Berthelsen serves as Executive at ISIS PHARMACEUTICALS INC, where they oversee executive responsibilities. Since joining the company, Spencer R. Berthelsen has executed 84 insider transactions totaling $4.0M, demonstrating a bearish approach to their equity position. Their most recent transaction on Jul 15, 2025 involved exercising options for 4,079 shares valued at $0.
Spencer R. Berthelsen currently holds 156,013 shares of ISIS PHARMACEUTICALS INC (ISIS), valued at approximately $0. This represents their equity stake as Executive.
Based on SEC Form 4 filings, Spencer R. Berthelsen has been a net seller of ISIS stock. They have purchased $0 and sold $4.0M worth of shares.
Spencer R. Berthelsen's most recent insider trade was on Jul 15, 2025, when they sold 4,079 shares at $0.00 per share.
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| 4,677 |
| $N/A |
| Discretionary |
| Jun 17, 2024 | IONS | $644.6K | Sale | 16,000 | $40.29 | Planned |
| Jun 17, 2024 | IONS | $568.5K | Option Exercise | 16,000 | $35.53 | Planned |
| Jul 17, 2023 | IONS | $0 | Option Exercise | 1,777 | $N/A | Discretionary |
| Jul 17, 2023 | IONS | $0 | Option Exercise | 5,333 | $N/A | Discretionary |
| Jun 20, 2023 | IONS | $320.3K | Option Exercise | 11,250 | $28.47 | Discretionary |
| Jul 15, 2022 | IONS | $0 | Option Exercise | 5,333 | $N/A | Discretionary |
| Jul 15, 2022 | IONS | $0 | Option Exercise | 2,665 | $N/A | Discretionary |
| Jun 7, 2022 | IONS | $145.6K | Option Exercise | 11,250 | $12.94 | Discretionary |
| Jul 15, 2021 | IONS | $0 | Option Exercise | 889 | $N/A | Discretionary |
| Jul 15, 2021 | IONS | $0 | Option Exercise | 666 | $N/A | Discretionary |
| Jul 15, 2021 | IONS | $0 | Option Exercise | 1,778 | $N/A | Discretionary |
| Jul 15, 2021 | IONS | $0 | Option Exercise | 5,333 | $N/A | Discretionary |
| Jun 23, 2021 | IONS | $139.5K | Option Exercise | 15,000 | $9.30 | Discretionary |
| Jun 23, 2021 | IONS | $566.1K | Sale | 15,000 | $37.74 | Discretionary |
| Jul 6, 2020 | IONS | $0 | Option Exercise | 667 | $N/A | Discretionary |
| Jul 2, 2020 | IONS | $0 | Option Exercise | 889 | $N/A | Discretionary |
| Jul 1, 2020 | IONS | $0 | Option Exercise | 1,778 | $N/A | Discretionary |
| Jul 1, 2020 | IONS | $0 | Option Exercise | 666 | $N/A | Discretionary |
| Jun 23, 2020 | IONS | $881.4K | Sale | 15,000 | $58.76 | Discretionary |
| Jun 23, 2020 | IONS | $138.3K | Option Exercise | 15,000 | $9.22 | Discretionary |
| Jul 3, 2019 | IONS | $0 | Option Exercise | 667 | $N/A | Discretionary |
| Jul 2, 2019 | IONS | $0 | Option Exercise | 889 | $N/A | Discretionary |
| Jul 1, 2019 | IONS | $0 | Option Exercise | 666 | $N/A | Discretionary |
| Jul 1, 2019 | IONS | $0 | Option Exercise | 667 | $N/A | Discretionary |
| Jun 24, 2019 | IONS | $618.6K | Sale | 9,690 | $63.84 | Discretionary |
| Jun 24, 2019 | IONS | $158.1K | Option Exercise | 9,690 | $16.32 | Discretionary |
| Jun 24, 2019 | IONS | $336.5K | Sale | 5,310 | $63.37 | Discretionary |
| Jun 24, 2019 | IONS | $86.7K | Option Exercise | 5,310 | $16.32 | Discretionary |